Fallout mod manager crash on startup

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I have tried to run Fallout 4, 312 times in the past 3 weeks and it only 9 times did a new game or loaded a save file work, when i used the direct files f4se_loader.exe, Fallout4.exe, and Fallout4Launcher.exe directly. 0 mods or 498 mods does not matter, this is a new one for me.

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If i use Mod Organizer 2.2.2.1 Fallout 4crashes in 15 seconds no error, when i load a save game or start a new game.